CDK17/cyclin Y Kinase Enzyme Activity Assay Kit
The CDK17/cyclin Y Kinase Enzyme Activity Assay Kit offers a validated, ready-to-use biochemical assay based on the renowned ADP Hunter™ Plus Assay platform from DiscoverX for accurately measuring kinase inhibitor efficacy. The kit includes recombinant CDK17/cyclin Y, substrate, ATP, detection reagents, and assay plates, enabling precise quantification of ADP accumulation. Designed to handle elevated ATP concentrations, this assay delivers robust, reliable data ideal for high-throughput screening (HTS) and other drug discovery applications.
Biological information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for CDK17/cyclin Y. It comes with all essential components, including recombinant CDK17/cyclin Y (Eurofins #16-042), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
CDK17 is a cyclin-dependent kinase primarily regulated by cyclin Y–like partners. It is most highly expressed in neuronal tissues and is thought to phosphorylate serine/threonine residues on substrates, including histone H1. It may play roles in terminally differentiated neurons, although its precise physiological functions are not yet well defined. Proteomic analyses indicate that CDK17 expression and phosphorylation are increased in amyloid precursor protein-expressing neuroblastoma cells and in brains of Alzheimer’s disease (AD) transgenic mice and human AD subjects, suggesting altered CDK17 regulation in AD pathology.
Product specifications
Chemical data
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for CDK17/cyclin Y. It comes with all essential components, including recombinant CDK17/cyclin Y (Eurofins #16-042), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
CDK17 is a cyclin-dependent kinase primarily regulated by cyclin Y–like partners. It is most highly expressed in neuronal tissues and is thought to phosphorylate serine/threonine residues on substrates, including histone H1. It may play roles in terminally differentiated neurons, although its precise physiological functions are not yet well defined. Proteomic analyses indicate that CDK17 expression and phosphorylation are increased in amyloid precursor protein-expressing neuroblastoma cells and in brains of Alzheimer’s disease (AD) transgenic mice and human AD subjects, suggesting altered CDK17 regulation in AD pathology.
Product specifications
Kinase Activity Assay Biological information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for CDK17/cyclin Y. It comes with all essential components, including recombinant CDK17/cyclin Y (Eurofins #16-042), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
CDK17 is a cyclin-dependent kinase primarily regulated by cyclin Y–like partners. It is most highly expressed in neuronal tissues and is thought to phosphorylate serine/threonine residues on substrates, including histone H1. It may play roles in terminally differentiated neurons, although its precise physiological functions are not yet well defined. Proteomic analyses indicate that CDK17 expression and phosphorylation are increased in amyloid precursor protein-expressing neuroblastoma cells and in brains of Alzheimer’s disease (AD) transgenic mice and human AD subjects, suggesting altered CDK17 regulation in AD pathology.
PCTK2; PCTAIRE2 (CDK17)
Kinase Activity Assay Usage
For Research Use Only
Kinase Activity Assay Information
Biological Information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for CDK17/cyclin Y. It comes with all essential components, including recombinant CDK17/cyclin Y (Eurofins #16-042), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
CDK17 is a cyclin-dependent kinase primarily regulated by cyclin Y–like partners. It is most highly expressed in neuronal tissues and is thought to phosphorylate serine/threonine residues on substrates, including histone H1. It may play roles in terminally differentiated neurons, although its precise physiological functions are not yet well defined. Proteomic analyses indicate that CDK17 expression and phosphorylation are increased in amyloid precursor protein-expressing neuroblastoma cells and in brains of Alzheimer’s disease (AD) transgenic mice and human AD subjects, suggesting altered CDK17 regulation in AD pathology.
Product Specifications
For Research Use Only
Biological Information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for CDK17/cyclin Y. It comes with all essential components, including recombinant CDK17/cyclin Y (Eurofins #16-042), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
CDK17 is a cyclin-dependent kinase primarily regulated by cyclin Y–like partners. It is most highly expressed in neuronal tissues and is thought to phosphorylate serine/threonine residues on substrates, including histone H1. It may play roles in terminally differentiated neurons, although its precise physiological functions are not yet well defined. Proteomic analyses indicate that CDK17 expression and phosphorylation are increased in amyloid precursor protein-expressing neuroblastoma cells and in brains of Alzheimer’s disease (AD) transgenic mice and human AD subjects, suggesting altered CDK17 regulation in AD pathology.
Product Specifications
For Research Use Only