Native Full-Length Membrane Proteins for Drug Discovery

CALIXAR delivers the highest-quality membrane proteins used for drug discovery. Our products and services are adapted to pharmaceutical, biotechnology companies, as well as academic teams that are involved in life science.

Products and services

A world reference in native membrane protein isolation

Our membrane proteins are among the best in the world for developing new drugs, antibodies, formulating vaccines and discovering primary leads through Structure-Based Drug Design or High Throughput Screening assays.

Purified membrane proteins and customized detergents

CALIXAR's pipeline contains native and functional membrane targets ready for the discovery. Our patented technology has a significant impact on membrane protein’s conformity and quality. We have developed surfactant-based detergents that maintain the functional and structural integrity of membrane proteins.

Membrane protein discovery, production and validation

CALIXAR guides its clients fin defining the best expression, solubilization, and stabilization conditions for specific targets. Having these challenging membrane proteins stabilized (native and functional) in full length format is crucial to secure the relevance of new leads, and further to increase success in clinical stages.


New membrane protein discovery

CALIXAR’s technology is capable of producing high quality, native, wild-type, unaltered, unmutated and untruncated targets for antibody development and drug discovery projects.
We are unique in the market and are at the forefront of Membrane Protein technology.

Due to our patented technology and expertise, we are able to manufacture membrane proteins that sustain the structure and function of the target. Our membrane proteins are pure, native, unaltered and stable. They can also able bind to a wide and broad scope of compounds including agonists, antagonists, and allosteric modulators.

CALIXAR's pipeline is composed of a wide range of native membrane targets: GPCRs & Receptors, Ion Channels & Enzymes, MDR & AMR Targets. We are continuously developing the most challenging targets to meet the needs of the life science discovery market.


How we can fit your needs

The CALIXAR® platform utilizes patented technology only available for clients under specific agreements (license, co-development, and service).You can leverage our proprietary technology as well as other best-in-class membrane protein technology that is not available anywhere else on the market.

Antibody discovery

Our antibody expertise produces native and stable membrane proteins for conformational antibody discovery.

Drug discovery

We manufacture full length, highly pure membrane proteins via native isolation used for drug discovery projects.

Vaccine discovery

We conduct exhaustive internal research efforts on specific membrane antigens adapted to discovery projects.


We maintain the structural and functional integrities of antigens yielding accurate recognition of specific antibodies.


How we can fit your needs

The CALIXAR® platform utilizes patented technology only available for clients under specific agreements (license, co-development, and service). You can leverage our proprietary technology as well as other best-in-class membrane protein technology that is not available anywhere else on the market.


Drug discovery

Drug discovery

Drug discovery

CALIXAR produces native and functional membrane protein targets for the discovery of new hits, leads or compounds with greater affinity.


Antibody discovery

Antibody discovery

Antibody discovery

CALIXAR’s technology maintains the structural and functional integrities of the antigen to develop conformational antibodies with therapeutic potential.


Structure determination

Structure determination

Structure determination

CALIXAR helps you better understand the mechanisms of action, optimize research leads and solve high-resolution structures or co-structure of membrane proteins.


Vaccine discovery

Vaccine discovery

Vaccine discovery

CALIXAR produces high-quality, native, pure, and functional antigens for vaccine discovery.


Biological assays

Biological assays

Biological assays

CALIXAR provides high-quality membrane protein biochemical assays and characterization services for scientists and researchers.


A unique and native process

Conventional approaches tend to modify the protein through deletions or point mutations to make it adapted to the environment. Instead, CALIXAR’s approach modifies the chemical environment that will adapt to the proteins/antigens chemistry.

Our process permits the preservation of the functional and structural integrities of the targets/antigens. This has a significantly positive result on the quality of the protein and on the success of the proteomics and drug discovery applications.

Better Discovery

Uncover reliable and efficient drugs and antibodies as they are not locked in any particular conformation.

Native Proteins

CALIXAR is the preeminent lab to produce native, wild-type, unmutated and untruncated targets for drug/antibody/vaccine discovery.

Made for Pharma/Biotech

Our high-quality membrane proteins are adapted to application in pharmaceutical, biotechnology firms, and academic teams.

Proprietary Technology

All of our clients gain access to our proprietary technology and expertise. (7 patent families, 20 publications).

Any Life science

Antibodies (nanobodies, scaffold proteins, aptamers, Small molecules, 3D Structures (X-ray or XFEL, Cryo-EM, NMR)

At any stage

Purified membrane proteins are adapted to drug discovery, antibody development and drug validation at any clinical stage.


Latest news, events, press releases and related news

April 28, 2023

CALIXAR will attend the Protein & Antibody Engineering Summit (PEGS US) on May 15 – 19 2023 at Boston

Press releases
April 6, 2023

Eurofins Discovery Acquires CALIXAR, Expanding Integrated Drug Discovery Capabilities and Expertise

March 24, 2023

Résultats de l’année 2022 - Results of the year 2022

March 10, 2023

CALIXAR obtient le renouvellement de son agrément « Crédit d’Impôt Recherche » (CIR) pour 5 ans

March 3, 2023

CALIXAR will participate to the 7th AMR Conference at Basel (Switzerland) on March 16 - 17, 2023

February 24, 2023

Calixar: target proteins for drug development

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.