Native Full-Length Membrane Proteins for Drug Discovery
CALIXAR delivers the highest-quality membrane proteins used for drug discovery. Our products and services are adapted to pharmaceutical, biotechnology companies, as well as academic teams that are involved in life science.
A world reference in native membrane protein isolation
Our membrane proteins are among the best in the world for developing new drugs, antibodies, formulating vaccines and discovering primary leads through Structure-Based Drug Design or High Throughput Screening assays.
Purified membrane proteins and customized detergents
CALIXAR's pipeline contains native and functional membrane targets ready for the discovery. Our patented technology has a significant impact on membrane protein’s conformity and quality. We have developed surfactant-based detergents that maintain the functional and structural integrity of membrane proteins.
Membrane protein discovery, production and validation
CALIXAR guides its clients fin defining the best expression, solubilization, and stabilization conditions for specific targets. Having these challenging membrane proteins stabilized (native and functional) in full length format is crucial to secure the relevance of new leads, and further to increase success in clinical stages.
New membrane protein discovery
CALIXAR’s technology is capable of producing high quality, native, wild-type, unaltered, unmutated and untruncated targets for antibody development and drug discovery projects.
We are unique in the market and are at the forefront of Membrane Protein technology.
Due to our patented technology and expertise, we are able to manufacture membrane proteins that sustain the structure and function of the target. Our membrane proteins are pure, native, unaltered and stable. They can also able bind to a wide and broad scope of compounds including agonists, antagonists, and allosteric modulators.
CALIXAR's pipeline is composed of a wide range of native membrane targets: GPCRs & Receptors, Ion Channels & Enzymes, MDR & AMR Targets. We are continuously developing the most challenging targets to meet the needs of the life science discovery market.
How we can fit your needs
The CALIXAR® platform utilizes patented technology only available for clients under specific agreements (license, co-development, and service).You can leverage our proprietary technology as well as other best-in-class membrane protein technology that is not available anywhere else on the market.
Antibody discovery
Our antibody expertise produces native and stable membrane proteins for conformational antibody discovery.
Drug discovery
We manufacture full length, highly pure membrane proteins via native isolation used for drug discovery projects.
Vaccine discovery
We conduct exhaustive internal research efforts on specific membrane antigens adapted to discovery projects.
Immunoassays
We maintain the structural and functional integrities of antigens yielding accurate recognition of specific antibodies.
How we can fit your needs
The CALIXAR® platform utilizes patented technology only available for clients under specific agreements (license, co-development, and service). You can leverage our proprietary technology as well as other best-in-class membrane protein technology that is not available anywhere else on the market.
Drug discovery
Drug discovery
Drug discovery
CALIXAR produces native and functional membrane protein targets for the discovery of new hits, leads or compounds with greater affinity.
Antibody discovery
Antibody discovery
Antibody discovery
CALIXAR’s technology maintains the structural and functional integrities of the antigen to develop conformational antibodies with therapeutic potential.
Structure determination
Structure determination
Structure determination
CALIXAR helps you better understand the mechanisms of action, optimize research leads and solve high-resolution structures or co-structure of membrane proteins.
Vaccine discovery
Vaccine discovery
Vaccine discovery
CALIXAR produces high-quality, native, pure, and functional antigens for vaccine discovery.
Biological assays
Biological assays
Biological assays
CALIXAR provides high-quality membrane protein biochemical assays and characterization services for scientists and researchers.
A unique and native process
Conventional approaches tend to modify the protein through deletions or point mutations to make it adapted to the environment. Instead, CALIXAR’s approach modifies the chemical environment that will adapt to the proteins/antigens chemistry.
Our process permits the preservation of the functional and structural integrities of the targets/antigens. This has a significantly positive result on the quality of the protein and on the success of the proteomics and drug discovery applications.
Better Discovery
Uncover reliable and efficient drugs and antibodies as they are not locked in any particular conformation.
Native Proteins
CALIXAR is the preeminent lab to produce native, wild-type, unmutated and untruncated targets for drug/antibody/vaccine discovery.
Made for Pharma/Biotech
Our high-quality membrane proteins are adapted to application in pharmaceutical, biotechnology firms, and academic teams.
Proprietary Technology
All of our clients gain access to our proprietary technology and expertise. (7 patent families, 20 publications).
Any Life science
Antibodies (nanobodies, scaffold proteins, aptamers, Small molecules, 3D Structures (X-ray or XFEL, Cryo-EM, NMR)
At any stage
Purified membrane proteins are adapted to drug discovery, antibody development and drug validation at any clinical stage.
