JMJD2E
N-terminal 6His-tagged recombinant amino acids 1-336, human JMJD2E.
Biological information
Background
JMJD2E (Jumonji domain-containing protein 2E), also known as KDM4E, is a histone demethylase that belongs to the JmjC domain-containing protein family. Like other members of this family, JMJD2E specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2E is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2E has been implicated in the development of several types of cancer, including breast, ovarian, and prostate cancers. Additionally, recent studies have suggested that JMJD2E is involved in the regulation of pluripotency and differentiation of embryonic stem cells. Therefore, JMJD2E has emerged as a potential target for the development of novel therapeutics for cancer, metabolic diseases, and regenerative medicine.
Target class
Epigenetic
Family
Accession number
NP_001155102
Target Name
JMJD2E
Target Alias
KDM4E
Origin
Human
Theori. MW
41.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Hepes/NaOH pH 7.4,
250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD2E (Jumonji domain-containing protein 2E), also known as KDM4E, is a histone demethylase that belongs to the JmjC domain-containing protein family. Like other members of this family, JMJD2E specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2E is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2E has been implicated in the development of several types of cancer, including breast, ovarian, and prostate cancers. Additionally, recent studies have suggested that JMJD2E is involved in the regulation of pluripotency and differentiation of embryonic stem cells. Therefore, JMJD2E has emerged as a potential target for the development of novel therapeutics for cancer, metabolic diseases, and regenerative medicine.
Compound name
Epigenetic
Catalog number
EPI033
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI033
Datasheet