JMJD2D
N-terminal 6His-tagged recombinant amino acids 1-358, human JMJD2D.
Biological information
Background
JMJD2D (Jumonji domain-containing protein 2D), also known as KDM4D, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2D is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2D has been shown to play a role in the development of several types of cancer, including breast, ovarian, and prostate cancers. It has also been implicated in the regulation of cellular metabolism, including the response to hypoxia and glucose metabolism. Therefore, JMJD2D has emerged as a potential target for the development of novel therapeutics for cancer and metabolic diseases.
Target class
Epigenetic
Family
Accession number
NP_060509.2
Target Name
JMJD2D
Target Alias
KDM4D
Origin
Human
Theori. MW
43.8 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Hepes/NaOH pH
7.5, 250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD2D (Jumonji domain-containing protein 2D), also known as KDM4D, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2D is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2D has been shown to play a role in the development of several types of cancer, including breast, ovarian, and prostate cancers. It has also been implicated in the regulation of cellular metabolism, including the response to hypoxia and glucose metabolism. Therefore, JMJD2D has emerged as a potential target for the development of novel therapeutics for cancer and metabolic diseases.
Compound name
Epigenetic
Catalog number
EPI032
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI032
Datasheet