JMJD2C
Recombinant human JMJD2C amino acids 1-366.
Biological information
Background
JMJD2C (Jumonji domain-containing protein 2C), also known as KDM4C, is a histone demethylase that belongs to the JmjC domain-containing protein family. Like other members of this family, JMJD2C specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2C is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2C has been implicated in the development of several types of cancer, including breast, ovarian, and colorectal cancers. It has also been shown to play a role in the regulation of various viral infections, including human papillomavirus (HPV) and hepatitis B virus (HBV). Therefore, JMJD2C has emerged as a potential target for the development of novel therapeutics for cancer and viral infections.
Target class
Epigenetic
Family
Accession number
NP_055876.2
Target Name
JMJD2C
Target Alias
bA146B14.1, FLJ25949, GASC1, JHDM3C, KDM4C, KIAA0780
Origin
Human
Theori. MW
42.6 kDa
Affinity tag
TEV protease
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Hepes/NaOH pH
7.5, 250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD2C (Jumonji domain-containing protein 2C), also known as KDM4C, is a histone demethylase that belongs to the JmjC domain-containing protein family. Like other members of this family, JMJD2C specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2C is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2C has been implicated in the development of several types of cancer, including breast, ovarian, and colorectal cancers. It has also been shown to play a role in the regulation of various viral infections, including human papillomavirus (HPV) and hepatitis B virus (HBV). Therefore, JMJD2C has emerged as a potential target for the development of novel therapeutics for cancer and viral infections.
Compound name
Epigenetic
Catalog number
EPI031
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI031
Datasheet