KAT2A (GCN5L2)
Recombinant human KAT2A (GCN5L2) amino acids 497-662.
Biological information
Background
KAT2A, also known as GCN5L2 (general control of amino acid synthesis protein 5-like 2), is an epigenetic protein that functions as a histone acetyltransferase (HAT). It is responsible for adding acetyl groups to specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. KAT2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant KAT2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. KAT2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.
Target class
Epigenetic
Family
Accession number
NP_066564.2
Target Name
KAT2A (GCN5L2)
Target Alias
PCAF-b
Origin
Human
Theori. MW
19.3 kDa
Affinity tag
Thrombin protease
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Tris/HCl pH7.4,
250mM NaCl, 50% Glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
KAT2A, also known as GCN5L2 (general control of amino acid synthesis protein 5-like 2), is an epigenetic protein that functions as a histone acetyltransferase (HAT). It is responsible for adding acetyl groups to specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. KAT2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant KAT2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. KAT2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.
Compound name
Epigenetic
Catalog number
EPI024
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI024
Datasheet