c-Cbl (c-Myc tagged) activated
N-Terminal c-Myc and GST-tagged, recombinant, human c-Cbl, full length, expressed by baculovirus in Sf21 insect cells.
No items found.
Biological information
Background
c-Cbl is a cellular protein that belongs to the family of Cbl proteins. It acts as an E3 ubiquitin ligase and is involved in regulating the degradation of various proteins in the cell. c-Cbl has several functions in different cellular processes, including receptor downregulation, signal transduction, and cytoskeletal organization. c-Cbl is also involved in signal transduction, where it can be recruited to activated receptors or intracellular signaling proteins to regulate their downstream signaling pathways.
Dysregulation of c-Cbl has been associated with several human diseases, including cancer, immune disorders, and neurodegenerative diseases. Purified using glutathione sepharose, activated in vitro with Src (cat # 14-746).
Target class
Ubiquitin
Family
E3
Accession number
GenBank NM_005188
Target Name
c-Cbl (c-Myc tagged) activated
Target Alias
C-CBL, CBL2, FRA11B, NSLL, RNF55
Origin
Human
Theori. MW
129 kDa
Affinity tag
N-terminal c-Myc, GST-tag
Product specifications
Expression system
expressed in insect cells
Purity
66%
Purification method
Glutathione sepharose
Sample Buffer
0.629 mg/ml of enzyme in 30 mM Tris/HCl pH 7.5, 10 mM MOPS pH 7.5, 90 mM NaCl, 12 mM MgCl2, 0.05 µM Src, 100 µM ATP, 0.06 mM EGTA, 0.018% Brij-35, 0.004% Tween 20, 5 mM β-glycerophosphate, 1 mM sodium orthovanadate, 162 mM sucrose, 0.6 mM benzamidine, 0.12 mM PMSF, 0.06% 2-mercaptoethanol, Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
c-Cbl is a cellular protein that belongs to the family of Cbl proteins. It acts as an E3 ubiquitin ligase and is involved in regulating the degradation of various proteins in the cell. c-Cbl has several functions in different cellular processes, including receptor downregulation, signal transduction, and cytoskeletal organization. c-Cbl is also involved in signal transduction, where it can be recruited to activated receptors or intracellular signaling proteins to regulate their downstream signaling pathways.
Dysregulation of c-Cbl has been associated with several human diseases, including cancer, immune disorders, and neurodegenerative diseases. Purified using glutathione sepharose, activated in vitro with Src (cat # 14-746).
Compound name
Ubiquitin
Catalog number
23-061
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
c-Cbl is a cellular protein that belongs to the family of Cbl proteins. It acts as an E3 ubiquitin ligase and is involved in regulating the degradation of various proteins in the cell. c-Cbl has several functions in different cellular processes, including receptor downregulation, signal transduction, and cytoskeletal organization. c-Cbl is also involved in signal transduction, where it can be recruited to activated receptors or intracellular signaling proteins to regulate their downstream signaling pathways.
Dysregulation of c-Cbl has been associated with several human diseases, including cancer, immune disorders, and neurodegenerative diseases. Purified using glutathione sepharose, activated in vitro with Src (cat # 14-746).
Target class
Ubiquitin
Family
E3
Subfamily
Protein Name
c-Cbl
Protein Alias
C-CBL, CBL2, FRA11B, NSLL, RNF55
Accession Number
GenBank NM_005188
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures