ATR/ATRIP, active Human Recombinant Kinase Protein
Recombinant, human FLAG-tagged ATR full length and recombinant, human cMyc-tagged ATRIP full length.
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Biological information
Background
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Target class
Kinase
Family
PI3/PI4-Kinase
Accession number
NM_001184.3; AF451323.1
Target Name
ATR/ATRIP, active Human Recombinant Kinase Protein
Target Alias
Origin
Human
Theori. MW
303 kDa (ATR), 87 kDa (ATRIP)
Affinity tag
FLAG, c-Myc
Product specifications
Expression system
Expressed in a mammalian cell line
Purity
Purity 50% by SDS-PAGE and Coomassie blue staining.
Purification method
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Compound name
Kinase
Catalog number
14-953
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Target class
Kinase
Family
PI3/PI4-Kinase
Subfamily
Protein Name
ATR/ATRIP
Protein Alias
Accession Number
NM_001184.3; AF451323.1
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures