NIM1, active
N-terminal GST-tagged recombinant, human full length NIM1.
No items found.
Biological information
Background
NIM1 (Never in mitosis A-related kinase 1) is a serine/threonine protein kinase that belongs to the NIMA-related kinase (NEK) family of kinases. It is involved in a variety of cellular processes, including regulation of the cell cycle, DNA damage response, and apoptosis. Research has suggested that NIM1 plays a role in several diseases, including cancer, neurodegenerative diseases, and inflammation. In cancer, NIM1 has been shown to promote tumor growth and survival, and inhibition of NIM1 has been suggested as a potential cancer therapy. In neurodegenerative diseases, NIM1 has been implicated in the regulation of neuronal survival and degeneration, and alterations in NIM1 expression have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. Additionally, NIM1 has been implicated in the regulation of the immune response, making it a potential target for the treatment of inflammatory diseases.
Target class
Kinase
Family
CAMK
Accession number
NM_153361
Target Name
NIM1, active
Target Alias
Origin
Human
Theori. MW
77 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 94% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography; Gel filtration
Sample Buffer
Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
NIM1 (Never in mitosis A-related kinase 1) is a serine/threonine protein kinase that belongs to the NIMA-related kinase (NEK) family of kinases. It is involved in a variety of cellular processes, including regulation of the cell cycle, DNA damage response, and apoptosis. Research has suggested that NIM1 plays a role in several diseases, including cancer, neurodegenerative diseases, and inflammation. In cancer, NIM1 has been shown to promote tumor growth and survival, and inhibition of NIM1 has been suggested as a potential cancer therapy. In neurodegenerative diseases, NIM1 has been implicated in the regulation of neuronal survival and degeneration, and alterations in NIM1 expression have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. Additionally, NIM1 has been implicated in the regulation of the immune response, making it a potential target for the treatment of inflammatory diseases.
Compound name
Kinase
Catalog number
14-945
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-945
Datasheet