p38α/SAPK2a (T106M), active
10 µg of active p38α/SAPK2a. N-terminal GST-tagged recombinant, human full length p38α/SAPK2a containing the mutation T106M.
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Biological information
Background
N-terminal GST-tagged recombinant, human full length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione-agarose. Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.
Target class
Kinase
Family
CMGC
Accession number
NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1
Target Name
p38α/SAPK2a (T106M), active
Target Alias
MAPK14, p38, CSBP, PRKM15, PRKM14, RK, SAPK2A, CSBP1, CSPB1, Mxi2, p38ALPHA, MXI2, EXIP, CSBP2
Origin
Human
Theori. MW
67.7 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
N-terminal GST-tagged recombinant, human full length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione-agarose. Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.
Compound name
Kinase
Catalog number
14-687
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-687
Datasheet