Ret, active
N-terminal GST-tagged recombinant, human Ret amino acids 658-end.
No items found.
Biological information
Background
The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschspung disease or colonic aganglionosis).
GenBank NM_000323
Target class
Kinase
Family
TK
Accession number
NM_020630.4; NM_020975.4
Target Name
Ret, active
Target Alias
RET, HSCR1, MEN2A, PTC, CDHF12, RET51, RET-ELE1, C-ret, MTC1, MEN2B
Origin
Human
Theori. MW
79.2 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschspung disease or colonic aganglionosis).
GenBank NM_000323
Compound name
Kinase
Catalog number
14-570
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschspung disease or colonic aganglionosis).
GenBank NM_000323
Target class
Kinase
Family
TK
Subfamily
Protein Name
Ret
Protein Alias
RET, HSCR1, MEN2A, PTC, CDHF12, RET51, RET-ELE1, C-ret, MTC1, MEN2B
Accession Number
NM_020630.4; NM_020975.4
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures