TrkB, active
N-terminal 6His-tagged recombinant, human TrkB amino acids 455-end.
No items found.
Biological information
Background
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa.
GenBank U12140
Target class
Kinase
Family
TK
Accession number
U12140
Target Name
TrkB, active
Target Alias
NTRK2, GP145-TrkB, TRKB, Trk-B
Origin
Human
Theori. MW
42.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa.
GenBank U12140
Compound name
Kinase
Catalog number
14-507
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa.
GenBank U12140
Target class
Kinase
Family
TK
Subfamily
Protein Name
TrkB
Protein Alias
NTRK2, GP145-TrkB, TRKB, Trk-B
Accession Number
U12140
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa.
GenBank U12140
Target class
Kinase
Family
TK
Accession Number
U12140
Target Name
TrkB
Target Alias
NTRK2, GP145-TrkB, TRKB, Trk-B
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa.
GenBank U12140
Target class
Kinase
Family
TK
Accession Number
U12140
Target Name
TrkB
Target Alias
NTRK2, GP145-TrkB, TRKB, Trk-B
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only