IKKβ, active
N-terminal 6His-tagged recombinant, human full-length IKKβ.
No items found.
Biological information
Background
Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158
Target class
Kinase
Family
Other
Accession number
NM_001556.1
Target Name
IKKβ, active
Target Alias
IKBKB, IKK-B, IKK-beta, FLJ40509, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2
Origin
Human
Theori. MW
88 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158
Compound name
Kinase
Catalog number
14-485
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158
Target class
Kinase
Family
Other
Subfamily
Protein Name
IKKβ
Protein Alias
IKBKB, IKK-B, IKK-beta, FLJ40509, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2
Accession Number
NM_001556.1
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158
Target class
Kinase
Family
Other
Accession Number
NM_001556.1
Target Name
IKKβ
Target Alias
IKBKB, IKK-B, IKK-beta, FLJ40509, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158
Target class
Kinase
Family
Other
Accession Number
NM_001556.1
Target Name
IKKβ
Target Alias
IKBKB, IKK-B, IKK-beta, FLJ40509, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only