Monocarboxylate transporter 4

Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. Plays a predominant role in the transport of L-lactate efflux from highly glycolytic cells (By similarity).

PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry name:
MOT4_HUMAN
Gene name:
SLC16A3
Uniprot accession:
O15427
Origin:
Homo sapiens (Human)
Protein family:
Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13)
Full-length:
465
Mass:
49469
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes

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