Small regulatory polypeptide of amino acid response
[Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids. Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1. Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).
PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry name:
SPAR_HUMAN
Gene name:
SPAAR
Uniprot accession:
A0A1B0GVQ0
Origin:
Homo sapiens (Human)
Protein family:
nd
Full-length:
90
Mass:
9632
Sequence:
MGAKAPRGPKVAQWAMETAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQPVPSAQDFWTFM
