RIPK1, active
10 µg of active RIPK1.C-terminal 6His-tagged, recombinant, human RIPK1 amino acids 8-322.
No items found.
Biological information
Background
RIPK1 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Target class
Kinase
Family
TK-Like Kinase
Accession number
NM_003804.3
Target Name
RIPK1, active
Target Alias
Receptor Interacting Serine/Threonine Kinase 1Receptor (TNFRSF)-Interacting Serine-Threonine KinaseReceptor-Interacting Serine/Threonine-Protein Kinase 1Receptor-Interacting Protein Kinase 1Serine/Threonine-Protein Kinase RI
Origin
Human
Theori. MW
37 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 77% by SDS-PAGE and Coomassie
blue staining.
Purification method
Purified using immobilized metal affinity chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
RIPK1 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Compound name
Kinase
Catalog number
16-022
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
RIPK1 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Target class
Kinase
Family
TK-Like Kinase
Subfamily
Protein Name
RIPK1
Protein Alias
Receptor Interacting Serine/Threonine Kinase 1Receptor (TNFRSF)-Interacting Serine-Threonine KinaseReceptor-Interacting Serine/Threonine-Protein Kinase 1Receptor-Interacting Protein Kinase 1Serine/Threonine-Protein Kinase RI
Accession Number
NM_003804.3
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C.
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures