TTBK2, active
N-terminal GST-tagged, recombinant, human TTBK2 amino acids 1-331 expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose followed by size exclusion chromatography.
No items found.
Biological information
Background
TTBK2 (Tau tubulin kinase 2) is a serine/threonine protein kinase that is involved in a variety of cellular processes, including regulation of the cytoskeleton, intracellular transport, and neuronal development and function. TTBK2 has been shown to be involved in the regulation of microtubule dynamics and stability, and alterations in TTBK2 expression and activity have been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research has suggested that TTBK2 may also play a role in cancer. TTBK2 has been shown to be overexpressed in several types of cancer, including breast cancer and glioblastoma, and high levels of TTBK2 expression have been associated with poor prognosis. Additionally, TTBK2 has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.
Target class
Kinase
Family
Accession number
BC071556.1
Target Name
TTBK2, active
Target Alias
Origin
Human
Theori. MW
65 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 77% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose followed by size exclusion chromatography.
Sample Buffer
Protein in 50 mM Tris/HCl pH7.5,
300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose,
1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol.
Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
TTBK2 (Tau tubulin kinase 2) is a serine/threonine protein kinase that is involved in a variety of cellular processes, including regulation of the cytoskeleton, intracellular transport, and neuronal development and function. TTBK2 has been shown to be involved in the regulation of microtubule dynamics and stability, and alterations in TTBK2 expression and activity have been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research has suggested that TTBK2 may also play a role in cancer. TTBK2 has been shown to be overexpressed in several types of cancer, including breast cancer and glioblastoma, and high levels of TTBK2 expression have been associated with poor prognosis. Additionally, TTBK2 has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.
Compound name
Kinase
Catalog number
15-019
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
TTBK2 (Tau tubulin kinase 2) is a serine/threonine protein kinase that is involved in a variety of cellular processes, including regulation of the cytoskeleton, intracellular transport, and neuronal development and function. TTBK2 has been shown to be involved in the regulation of microtubule dynamics and stability, and alterations in TTBK2 expression and activity have been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research has suggested that TTBK2 may also play a role in cancer. TTBK2 has been shown to be overexpressed in several types of cancer, including breast cancer and glioblastoma, and high levels of TTBK2 expression have been associated with poor prognosis. Additionally, TTBK2 has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.
Target class
Kinase
Family
Subfamily
Protein Name
TTBK2
Protein Alias
Accession Number
BC071556.1
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures