CaM Kinase I γ, active
N-terminal GST-tagged recombinant, human full length CaM Kinase Iγ.
No items found.
Biological information
Background
CaM Kinase I γ (Calcium/Calmodulin-Dependent Protein Kinase I gamma) is a serine/threonine protein kinase that belongs to the CaM Kinase family of kinases. It is primarily expressed in the brain, where it plays a critical role in neuronal signaling and plasticity. CaM Kinase I γ is activated by binding of calcium and calmodulin, which leads to autophosphorylation and activation of the kinase. It has been shown to phosphorylate a variety of substrates, including ion channels, transcription factors, and other kinases, which contributes to the regulation of neuronal excitability, gene expression, and synaptic plasticity. Research has suggested that CaM Kinase I γ plays a critical role in several neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and bipolar disorder.
Target class
Kinase
Family
CAMK
Accession number
NM_020439.2
Target Name
CaM Kinase I γ, active
Target Alias
Origin
Human
Theori. MW
80 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 74% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography; Gel filtration
Sample Buffer
Protein in 50mM Tris/HCl pH7.5,
300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose,
1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
CaM Kinase I γ (Calcium/Calmodulin-Dependent Protein Kinase I gamma) is a serine/threonine protein kinase that belongs to the CaM Kinase family of kinases. It is primarily expressed in the brain, where it plays a critical role in neuronal signaling and plasticity. CaM Kinase I γ is activated by binding of calcium and calmodulin, which leads to autophosphorylation and activation of the kinase. It has been shown to phosphorylate a variety of substrates, including ion channels, transcription factors, and other kinases, which contributes to the regulation of neuronal excitability, gene expression, and synaptic plasticity. Research has suggested that CaM Kinase I γ plays a critical role in several neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and bipolar disorder.
Compound name
Kinase
Catalog number
14-967
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
CaM Kinase I γ (Calcium/Calmodulin-Dependent Protein Kinase I gamma) is a serine/threonine protein kinase that belongs to the CaM Kinase family of kinases. It is primarily expressed in the brain, where it plays a critical role in neuronal signaling and plasticity. CaM Kinase I γ is activated by binding of calcium and calmodulin, which leads to autophosphorylation and activation of the kinase. It has been shown to phosphorylate a variety of substrates, including ion channels, transcription factors, and other kinases, which contributes to the regulation of neuronal excitability, gene expression, and synaptic plasticity. Research has suggested that CaM Kinase I γ plays a critical role in several neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and bipolar disorder.
Target class
Kinase
Family
CAMK
Subfamily
Protein Name
CaM Kinase I γ
Protein Alias
Accession Number
NM_020439.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures