Rsk4, active
6His-tagged recombinant, human full length Rsk4.
No items found.
Biological information
Background
RSK4 (Ribosomal S6 kinase 4) is a serine/threonine protein kinase that belongs to the RSK (Ribosomal S6 kinase) family of kinases. It is involved in a variety of cellular processes, including cell growth and differentiation, transcriptional regulation, and cytoskeletal dynamics. Research has suggested that RSK4 plays a role in several diseases, including cancer and X-linked mental retardation. Mutations in the RSK4 gene have been linked to Coffin-Lowry syndrome, a rare genetic disorder characterized by intellectual disability, facial abnormalities, and other physical features. Additionally, RSK4 has been shown to be involved in the regulation of insulin signaling and glucose metabolism, making it a potential target for the treatment of type 2 diabetes.
Target class
Kinase
Family
AGC
Accession number
NM_014496.2
Target Name
Rsk4, active
Target Alias
RPS6KA6, RSK4, pp90RSK4, RSK-4
Origin
Human
Theori. MW
85.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 80.9% by SDSPAGE and Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50mM Tris/HCl pH7.5,
300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose,
1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
RSK4 (Ribosomal S6 kinase 4) is a serine/threonine protein kinase that belongs to the RSK (Ribosomal S6 kinase) family of kinases. It is involved in a variety of cellular processes, including cell growth and differentiation, transcriptional regulation, and cytoskeletal dynamics. Research has suggested that RSK4 plays a role in several diseases, including cancer and X-linked mental retardation. Mutations in the RSK4 gene have been linked to Coffin-Lowry syndrome, a rare genetic disorder characterized by intellectual disability, facial abnormalities, and other physical features. Additionally, RSK4 has been shown to be involved in the regulation of insulin signaling and glucose metabolism, making it a potential target for the treatment of type 2 diabetes.
Compound name
Kinase
Catalog number
14-702
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
RSK4 (Ribosomal S6 kinase 4) is a serine/threonine protein kinase that belongs to the RSK (Ribosomal S6 kinase) family of kinases. It is involved in a variety of cellular processes, including cell growth and differentiation, transcriptional regulation, and cytoskeletal dynamics. Research has suggested that RSK4 plays a role in several diseases, including cancer and X-linked mental retardation. Mutations in the RSK4 gene have been linked to Coffin-Lowry syndrome, a rare genetic disorder characterized by intellectual disability, facial abnormalities, and other physical features. Additionally, RSK4 has been shown to be involved in the regulation of insulin signaling and glucose metabolism, making it a potential target for the treatment of type 2 diabetes.
Target class
Kinase
Family
AGC
Subfamily
Protein Name
Rsk4
Protein Alias
RPS6KA6, RSK4, pp90RSK4, RSK-4
Accession Number
NM_014496.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures