PAK3, active
C-terminal 6His-tagged recombinant, human full length PAK3.
No items found.
Biological information
Background
PAK3 (P21 (RAC1) Activated Kinase 3) is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. PAK3 plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. PAK3 also plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity, and acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
GenBank AB102659
Target class
Kinase
Family
STE
Accession number
NM_002578.2
Target Name
PAK3, active
Target Alias
PAK3, oligophrenin-3, CDKN1A, OPHN3, PAK3beta, PAK-3, Beta-PAK, OTTHUMP00000062894, Oligophrenin-3, hPAK3, MRX47, MRX30, bPAK
Origin
Human
Theori. MW
63.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
PAK3 (P21 (RAC1) Activated Kinase 3) is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. PAK3 plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. PAK3 also plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity, and acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
GenBank AB102659
Compound name
Kinase
Catalog number
14-683
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-683
Datasheet