WNK2, active
N-terminal 6His-tagged recombinant, human WNK2 amino acids 166-489.
No items found.
Biological information
Background
WNK2 (WNK Lysine Deficient Protein Kinase 2) is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. WNK2 plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
GenBank NM_006648
Target class
Kinase
Family
STE
Accession number
NM_006648.3
Target Name
WNK2, active
Target Alias
WNK2, NY-CO-43, SDCCAG43, P/OKcl.13, PRKWNK2, KIAA1760, PRK
Origin
Human
Theori. MW
41.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
WNK2 (WNK Lysine Deficient Protein Kinase 2) is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. WNK2 plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
GenBank NM_006648
Compound name
Kinase
Catalog number
14-678
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
WNK2 (WNK Lysine Deficient Protein Kinase 2) is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. WNK2 plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
GenBank NM_006648
Target class
Kinase
Family
STE
Subfamily
Protein Name
WNK2
Protein Alias
WNK2, NY-CO-43, SDCCAG43, P/OKcl.13, PRKWNK2, KIAA1760, PRK
Accession Number
NM_006648.3
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures