CaM Kinase IV, active
C-terminal 6His-tagged recombinant, human full length CaM Kinase IV.
No items found.
Biological information
Background
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Target class
Kinase
Family
CAMK
Accession number
NM_001744.3
Target Name
CaM Kinase IV, active
Target Alias
CAMK4, MGC36771, CaMK-GR
Origin
Human
Theori. MW
52.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Compound name
Kinase
Catalog number
14-547
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Target class
Kinase
Family
CAMK
Subfamily
Protein Name
CaMKIV
Protein Alias
CAMK4, MGC36771, CaMK-GR
Accession Number
NM_001744.3
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures