PKD2, active
N-terminal 6His-tagged recombinant, human full length PKD2.
No items found.
Biological information
Background
Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCµ and PKCν. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts.
GenBank NM_016457
Target class
Kinase
Family
CAMK
Accession number
NM_001079880.1; NM_001079881.1; NM_001079882.1; NM_016457.4
Target Name
PKD2, active
Target Alias
PRKD2, DKFZP586E0820, PKD2, nPKC-D2, HSPC187
Origin
Human
Theori. MW
100 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCµ and PKCν. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts.
GenBank NM_016457
Compound name
Kinase
Catalog number
14-506
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCµ and PKCν. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts.
GenBank NM_016457
Target class
Kinase
Family
CAMK
Subfamily
Protein Name
PKD2
Protein Alias
PRKD2, DKFZP586E0820, PKD2, nPKC-D2, HSPC187
Accession Number
NM_001079880.1; NM_001079881.1; NM_001079882.1; NM_016457.4
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures