Rsk2/MAPKAP Kinase 1b, active Human Recombinant Kinase Protein
N-terminal 6His-tagged between Met1 and Pro2 recombinant, human full length RSK2.
No items found.
Biological information
Background
Rsk2, also known as Ribosomal Protein S6 Kinase A3, is a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
The protein sequence is identical to that described inGenBank NM_004586 for human RSK2, over residues 2–end. The cDNA however is more closely related to the mouse sequence described inGenBank AY083469.
Target class
Kinase
Family
AGC
Accession number
NM_004586.2
Target Name
Rsk2/MAPKAP Kinase 1b, active Human Recombinant Kinase Protein
Target Alias
RPS6KA3, CLS, RSK-2, RSK2, p90-RSK2, ISPK1, MRX19, HU-3, pp90RSK2, MAPKAPK1B, HU-2, RSK, S6K-alpha3, ISPK-1
Origin
Human
Theori. MW
88 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Rsk2, also known as Ribosomal Protein S6 Kinase A3, is a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
The protein sequence is identical to that described inGenBank NM_004586 for human RSK2, over residues 2–end. The cDNA however is more closely related to the mouse sequence described inGenBank AY083469.
Compound name
Kinase
Catalog number
14-480
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
Rsk2, also known as Ribosomal Protein S6 Kinase A3, is a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
The protein sequence is identical to that described inGenBank NM_004586 for human RSK2, over residues 2–end. The cDNA however is more closely related to the mouse sequence described inGenBank AY083469.
Target class
Kinase
Family
AGC
Subfamily
Protein Name
Rsk2
Protein Alias
RPS6KA3, CLS, RSK-2, RSK2, p90-RSK2, ISPK1, MRX19, HU-3, pp90RSK2, MAPKAPK1B, HU-2, RSK, S6K-alpha3, ISPK-1
Accession Number
NM_004586.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures