Integrated Protein Science Solutions to Advance Drug Discovery
From target design to decision-ready data, our Protein Science platform brings together custom protein production, advanced analytics, molecular interaction studies, and structural biology support.
Whether your project involves soluble proteins, complex membrane targets, GPCRs, enzymes, receptors, or challenging biologics, our integrated capabilities are designed to help you obtain high-quality, functional proteins and translate them into reliable insights for screening, hit validation, structural studies, and downstream drug discovery decisions.
Protein Production
High-quality protein is the foundation of every successful target-based discovery program. Our Protein Production capabilities cover the full workflow from construct design, gene optimization and expression to purification, formulation and scale-up. With extensive experience in both soluble and membrane proteins, including GPCRs, ion channels, transporters and other challenging targets, we develop tailored production strategies to deliver active, stable and highly purified proteins for screening, biophysics, functional assays and structural biology.
to see how we turn complex targets into reliable biological material for your discovery programs.
Protein Analytics
Reliable data starts with well-characterized proteins. Our Protein Analytics services provide the essential quality, purity, stability and functionality assessments needed to support confident decision-making. From purity and homogeneity analysis to aggregation monitoring, thermal stability profiling, oligomeric state determination, formulation screening and activity confirmation, we help ensure that every protein sample is fit for purpose before it enters critical downstream studies.
to understand how robust characterization strengthens reproducibility, assay performance and data interpretation.
Biophysics & Molecular Interactions
Understanding how molecules interact with their targets is central to hit identification, hit validation and optimization. Our Biophysics & Molecular Interactions platform combines complementary technologies such as SPR, MST, Spectral Shift, HT-Spectral Shift, ITC and thermal shift assays to measure affinity, kinetics, thermodynamics, stability changes and binding confirmation. These approaches support fragment-based discovery, affinity-based screening, SAR exploration, mechanism-of-action studies and orthogonal hit validation.
to discover how precise binding data can accelerate your path from hits to better compounds.
Structural Biology
Structural insight transforms biological targets into actionable drug discovery opportunities. Our Structural Biology capabilities connect protein production, extended QC, biophysical characterization and structure determination through Cryo-EM and X-ray crystallography partnerships. From challenging membrane proteins and large complexes to protein–ligand assemblies and structure-based drug design programs, we help generate high-resolution structural information that supports hit validation, binding mode interpretation and rational optimization.
to see how molecular structures can guide smarter design and accelerate your discovery strategy.
From capability to real drug discovery impact
To see how these capabilities translate into real drug discovery impact, explore our Protein Science case studies.
From complex membrane protein production and fragment-based screening to high-throughput biophysical hit identification and structure-enabled drug design, these examples illustrate how our integrated expertise can be applied to challenging targets and support confident decision-making at every stage of your discovery program.
Frequently Asked Questions
Protein Science at Eurofins Discovery combines Calixar’s protein leading expertise with a comprehensive platform for the expression, purification, and characterization of complex proteins; from challenging membrane targets like GPCRs and ion channels to soluble proteins such as kinases.
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