Identify molecules that directly engage your protein target with greater confidence. Using high-throughput spectral shift on Dianthus uHTS, spectral shift on MonolithX or Dianthus, MST/TRIC, and SPR, we support compound screening, fragment screening, and orthogonal hit confirmation. By directly measuring molecular binding rather than relying only on downstream functional readouts, our assays help prioritize high-quality starting points and reduce the risk of advancing false positives.

Move beyond “binds” or “does not bind” with quantitative interaction data. Our platforms measure affinity, kinetics, residence time, thermodynamics, and stoichiometry using SPR on Biacore 8K+, ITC on MicroCal PEAQ-ITC, MST/TRIC, and spectral shift approaches. These data help rank compounds, compare lead series, understand structure–activity relationships, and guide optimization strategies based on how molecules interact with their target.

Characterize how molecules modulate protein behavior and biological activity. SPR, ITC, MST/TRIC, and spectral shift methods can support studies of orthosteric and allosteric binding, conformational effects, target engagement, cooperativity, and ternary complex formation. These capabilities are particularly valuable for complex modalities such as PROTACs, molecular glues, peptides, antibodies, and nucleic acid binders, where understanding mechanism is critical to selecting the right candidates.

Reliable biophysical data starts with high-quality protein. We assess conformational integrity, thermal stability, aggregation behavior, and sample quality using nanoDSF and SLS/DLS on Prometheus Panta, as well as TSA on CFX384 and CFX Opus 384 systems. These studies help confirm that protein targets are suitable for screening and characterization, identify stabilizing conditions, improve assay robustness, and reduce downstream development risk.

Every protein, ligand, and research question is different. Our scientists help design the right biophysical workflow, selecting the most appropriate technology or orthogonal combination based on target class, modality, throughput, sample availability, and data needs. Whether you need rapid screening, detailed kinetic profiling, mechanistic insight, or stability assessment, we provide tailored strategies that turn molecular interaction data into actionable decisions.