How we work

Discover our PhD-led collaborative approach, milestone-driven timelines with seamless handoffs across protein science.

From initial sequence design through protein development, analytics, biophysics, and structural biology, our dedicated project teams deliver more than proteins, they deliver success. See exactly how we partner to accelerate your discovery timelines.

Custom Services

Talk to an expert

At Eurofins CALIXAR, we begin each project with an in-depth scientific assessment :

Because every protein and every project is unique, our scientific experts will guide you in customizing your protein development process to deliver material that is fully tailored to your needs.

AI-driven construct design& sequence optimization

Complete in-silico protein sequence analysis for prediction of sequence signal, transmembrane domains, and 3D structures.Protein construct design compatible with your final application.DNA sequence optimization to promote efficient protein cell expression and folding.

1

Expression system selection

Adapted cell expression system (bacteria, yeast, insect & mammalian cells) to the origin of the protein, the required post-translational modifications and the desired yield.

2

Application-specific format

Selection of specific protein formulation compatible with your downstream application (micelles of detergents, nanodiscs, amphipols, proteoliposomes).

3

Custom purification process

Purification procedure customized with suitable chromatography (affinity, ion-exchange, hydrophobicity, size-exclusion, ...), buffer composition (pH, salt, co-factors, ...) and quality controls (purity, quantity, monodispersity, cryo-stability, functional validation, ...).

4

Complete In-House Protein Workflow Management

We manage the entire workflow in-house, from construct design and expression to solubilization, stabilization, purification, characterization, large-scale production, and final protein qualification , ensuring both scientific consistency and the flexibility to adapt to your internal workflows or project stage.

Each of these steps is executed using our high-quality proprietary process, designed to maximize reproducibility, functional relevance, and downstream compatibility.Clients can rely on the complete process or select specific modules depending on their needs.

Deliverables & Scientific Collaboration, More Than Just a Protein

Eurofins CALIXAR delivers not just proteins, but high-performance reagents designed to integrate seamlessly into your discovery workflows. Each project is backed by precise documentation, validated data, and ongoing scientific interaction.

what you receive

Custom protein development

Pure, active & stable protein

Application-specific format (detergents, nanodiscs, amphipols, proteoliposomes)

Customized sampling (concentration, aliquoting, ....)

Empty buffer for dilution and controls

ALSO Included

Project Documentation

Technical report including experimental procedures

Results & data analysis

Protein QCs & buffer composition

Storage conditions & recommendations of use

what WE bring

Scientific Leadership

Calixar's scientific team lives and breathes native proteins! With 20+ years and PhD-driven leadership, we design, troubleshoot, and guide your projects with research-level rigor.

Clear communication

Kick-off meeting to define technical goals and success criteria, Weekly updates with Gantt timeline and milestone tracking, end-of-stage meetings with results review and recommendations

Real-time access

On-demand availability of your scientific coordinator, Direct scientist-to-scientist interactions for critical decisions and alignment

With Eurofins CALIXAR, you gain more than a deliverable, you engage a scientific partner committed to functional success.

Protein development

From gene design to purified protein, we deliver high-quality soluble and membrane proteins tailored for drug discovery, screening, biophysics, and structural biology projects.

Protein Analytics

Comprehensive protein characterization to confirm purity, stability, integrity, and functionality, ensuring confidence in downstream assays and decision-making.

Biophysics & Molecular Interactions

Quantitative binding, kinetics, and thermodynamic analysis using SPR, MST, Spectral Shift, and ITC to support screening, SAR, and mechanism-of-action studies.

Structural Biology

Cryo-EM and X-ray crystallography solutions delivering high-resolution protein structures to enable structure-based drug discovery and ligand optimization.

Your Partner at every step

Vincent Corvest PhD

Director of Scientific development | Protein Science

Contact our protein expert

Frequently Asked Questions

Eurofins Calixar is specialized in the expression, purification, and qualification of the most complex membrane and soluble proteins, from GPCRs to kinases.

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