MATK, active
10 µg of active MATK. C-terminal 6His-tagged, recombinant, human MATK full length.
Biological information
Background
MATK (Megakaryocyte-associated tyrosine kinase) is a non-receptor protein tyrosine kinase that belongs to the Src family of kinases. It is predominantly expressed in hematopoietic cells, particularly in megakaryocytes, platelets, and B cells. Research has suggested that MATK may be involved in the development and progression of several types of cancer, including breast cancer, leukemia, and lymphoma. In breast cancer, MATK has been shown to be upregulated in a subset of tumors, and may promote cancer cell growth and survival. In leukemia and lymphoma, MATK has been shown to be involved in the regulation of cell survival and proliferation, and may be a potential therapeutic target for the treatment of these diseases.
Target class
Kinase
Family
TK
Accession number
NM_139354.3
Target Name
MATK, active
Target Alias
Megakaryocyte-Associated Tyrosine Kinase; CTK; HYL; CHK; Hematopoietic Consensus Tyrosine-Lacking Kinase; Tyrosine-Protein Kinase CTK; Protein Kinase HYL
Origin
Human
Theori. MW
53k Da
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
75% by SDS-PAGE and Coomassie blue staining.
Purification method
Immobilised metal affinity chromatography
Sample Buffer
enzyme in 20 mM Hepes/NaOH pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.5 mM EGTA, 5 mM DTT, 50% glycerol. Frozen solution
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
MATK (Megakaryocyte-associated tyrosine kinase) is a non-receptor protein tyrosine kinase that belongs to the Src family of kinases. It is predominantly expressed in hematopoietic cells, particularly in megakaryocytes, platelets, and B cells. Research has suggested that MATK may be involved in the development and progression of several types of cancer, including breast cancer, leukemia, and lymphoma. In breast cancer, MATK has been shown to be upregulated in a subset of tumors, and may promote cancer cell growth and survival. In leukemia and lymphoma, MATK has been shown to be involved in the regulation of cell survival and proliferation, and may be a potential therapeutic target for the treatment of these diseases.
Compound name
Kinase
Catalog number
16-056
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
16-056
Datasheet