MLK3, active
10 µg of active MLK3. N-terminal GST-tagged, recombinant, human MLK3 amino acids 1-468.
Biological information
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Accession number
NM_002419.2
Target Name
MLK3, active
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase 11
MEKK11
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Mixed Lineage Kinase 3
SH3 Domain-Containing Proline-Rich Kinase
Protein-Tyrosine Kinase PTK1
EC 2.7.11
Origin
Human
Theori. MW
79 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 90% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Compound name
Kinase
Catalog number
16-039
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
16-039
Datasheet