PDHK2, active
10 µg of active PDHK2. N-terminal GST-tagged, recombinant, human PDHK2 full length.
Biological information
Background
PDHK2 is a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. [provided by RefSeq, Dec 2010]
Target class
Kinase
Family
Accession number
NM_002611.3
Target Name
PDHK2, active
Target Alias
Pyruvate Dehydrogenase Kinase 2[Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 2MitochondrialPyruvate Dehydrogenase KinaseIsoenzyme 2yruvate Dehydrogenase Kinase Isoform 2PDH Kinase 2
Origin
Human
Theori. MW
73 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
90% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
PDHK2 is a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. [provided by RefSeq, Dec 2010]
Compound name
Kinase
Catalog number
16-038
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
16-038
Datasheet