NEK4, active
10 µg of active NEK4. C-Terminal 6His-tagged, recombinant, human NEK4, full length.
Biological information
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Target class
Kinase
Family
Accession number
NM_003157.4
Target Name
NEK4, active
Target Alias
NIMA Related Kinase 4NIMA (Never In Mitosis Gene A)-Related KinaseSerine/Threonine-Protein Kinase Nek4Serine/Threonine-Protein Kinase NRK2Never In Mitosis A-Related Kinase 4Serine/Threonine Protein Kinase-2NimA-Related Protein Kinase 4
Origin
Human
Theori. MW
96 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
52% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immobilized metal affinity chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Compound name
Kinase
Catalog number
15-033
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
15-033
Datasheet