MAP4K3, active
10 µg of active MAP4K3. N-terminal GST-tagged and C-terminal 6His tagged, recombinant, human MAP4K3 amino acids 1-291.
Biological information
Background
MAP4K3 is a member of the mitogen-activated protein kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. Among its related pathways are TGF-Beta Pathway and Angiopoietin-like protein 8 regulatory pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.[provided by RefSeq, Jul 2012]
Target class
Kinase
Family
Ser/Thr Kinase
Accession number
NM_003618.2
Target Name
MAP4K3, active
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3Germinal Center Kinase-Related Protein KinaseMAPK/ERK Kinase Kinase Kinase 3MEK Kinase Kinase 3Germinal Center Kinase-Like Kinase
Origin
Human
Theori. MW
64 kDa
Affinity tag
GST, 6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 86% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using using immobilized metal affinity chromatography followed by glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
MAP4K3 is a member of the mitogen-activated protein kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. Among its related pathways are TGF-Beta Pathway and Angiopoietin-like protein 8 regulatory pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.[provided by RefSeq, Jul 2012]
Compound name
Kinase
Catalog number
15-030
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
15-030
Datasheet