MAP4K5, active
10 µg of active MAP4K5. N-terminal GST-tagged, recombinant, full length, human MAP4K5.
Biological information
Background
MAP4K5 is a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Ser/Thr Kinase
Accession number
NM_198794.4
Target Name
MAP4K5, active
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5MAPK/ERK Kinase Kinase Kinase 5Kinase Homologous To SPS1/STE20Germinal Center Kinase-RelatedMEK Kinase Kinase 5
Origin
Human
Theori. MW
122 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
42% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione-agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
MAP4K5 is a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Compound name
Kinase
Catalog number
15-004
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
15-004
Datasheet