PIP5K1α, active
N-terminal 6His-tagged recombinant, human PIP5K1α, full length.
No items found.
Biological information
Background
PIP5K1α (Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha) is a lipid kinase that phosphorylates phosphatidylinositol-4-phosphate (PI4P) to generate phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane. PIP2 is an important signaling molecule that regulates a variety of cellular processes, including cytoskeletal dynamics, ion channel activity, and membrane trafficking. Research has suggested that PIP5K1α plays a role in several diseases, including cancer, inflammatory disorders, and neurological disorders. It has been shown to promote cancer cell proliferation and invasion, and inhibition of PIP5K1α has been suggested as a potential cancer therapy. Additionally, PIP5K1α has been implicated in the regulation of immune cell function, making it a potential target for the treatment of autoimmune diseases and inflammatory disorders.
Target class
Kinase
Family
PIPK
Accession number
U78577
Target Name
PIP5K1α, active
Target Alias
PIP5K1A
Origin
Human
Theori. MW
60 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 73.6% by SDS-PAGE and Coomassie blue staining.
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 50mM Tris/HCl pH8.0, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
PIP5K1α (Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha) is a lipid kinase that phosphorylates phosphatidylinositol-4-phosphate (PI4P) to generate phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane. PIP2 is an important signaling molecule that regulates a variety of cellular processes, including cytoskeletal dynamics, ion channel activity, and membrane trafficking. Research has suggested that PIP5K1α plays a role in several diseases, including cancer, inflammatory disorders, and neurological disorders. It has been shown to promote cancer cell proliferation and invasion, and inhibition of PIP5K1α has been suggested as a potential cancer therapy. Additionally, PIP5K1α has been implicated in the regulation of immune cell function, making it a potential target for the treatment of autoimmune diseases and inflammatory disorders.
Compound name
Kinase
Catalog number
14-844
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-844
Datasheet