Met (M1268T), active
N-terminal 6His-tagged recombinant, human Met amino acids 974-end, containing the mutation M1268T. Met M1268T is a somatic mutation that has been identified in patients with papillary renal carcinomas (HPRC). In vitro studies have demonstrated enhanced kinase activity from this mutant.
No items found.
Biological information
Background
MET tyrosine kinase is a high-affinity receptor for hepatocyte growth factor/scatter factor. Signaling via this receptor-ligand pair has been shown to affect a wide range of biological activities, including angiogenesis, cellular motility, growth, invasion, and morphogenic differentiation. Mutations in the MET tyrosine kinase receptor have been identified in both hereditary and sporadic forms of papillary renal carcinoma and implicated in tumor growth, invasion, and metastasis.
GenBank J02958. The recombinant protein contains the amino acid substitutions A1209G and V1290L with reference toGenBank J02958. Both substitutions are reported inGenBank BU595386, BQ315895 and BQ316491.
Target class
Kinase
Family
TK
Accession number
J02958
Target Name
Met (M1268T), active
Target Alias
MET, AUTS9, c-Met, RCCP2, HGFR
Origin
Human
Theori. MW
50.1 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
MET tyrosine kinase is a high-affinity receptor for hepatocyte growth factor/scatter factor. Signaling via this receptor-ligand pair has been shown to affect a wide range of biological activities, including angiogenesis, cellular motility, growth, invasion, and morphogenic differentiation. Mutations in the MET tyrosine kinase receptor have been identified in both hereditary and sporadic forms of papillary renal carcinoma and implicated in tumor growth, invasion, and metastasis.
GenBank J02958. The recombinant protein contains the amino acid substitutions A1209G and V1290L with reference toGenBank J02958. Both substitutions are reported inGenBank BU595386, BQ315895 and BQ316491.
Compound name
Kinase
Catalog number
14-817
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-817
Datasheet