Pim-3, active
N-terminal 6His-tagged recombinant, human Pim-3.
No items found.
Biological information
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Target class
Kinase
Family
CAMK
Accession number
NM_001001852.2
Target Name
Pim-3, active
Target Alias
PIM3, pim-3
Origin
Human
Theori. MW
39.6 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 80% by SDS-PAGE and
Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50mM Tris/HCl pH7.5,
300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM
benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen
solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Compound name
Kinase
Catalog number
14-738
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-738
Datasheet