PDGFRα (550-end, V561D), active
10 µg of active PDGFRα. N-terminal 6His-tagged recombinant, human PDGFRα amino acids 550 - end, containing the V561D mutation.
No items found.
Biological information
Background
PDGFRα (Platelet-Derived Growth Factor Receptor Alpha) is a transmembrane receptor protein that belongs to the family of receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth, differentiation, migration, and survival. PDGFRα is expressed in a variety of tissues and cell types, including fibroblasts, smooth muscle cells, and certain types of cancer cells. Aberrant activation of PDGFRα has been implicated in several diseases, including cancer, fibrotic disorders, and vascular diseases. PDGFRα mutations, amplifications, and overexpression have been found in various types of cancer, making it a potential target for cancer therapy. Additionally, drugs that target PDGFRα have been approved for the treatment of certain types of cancer, such as gastrointestinal stromal tumors (GIST) and chronic myelomonocytic leukemia (CMML).
Target class
Kinase
Family
TK
Accession number
NM_006206.3
Target Name
PDGFRα (550-end, V561D), active
Target Alias
PDGFRA, CD140a, PDGF-R-alpha, MGC74795, PDGFR2, Rhe-PDGFRA, CD140A
Origin
Human
Theori. MW
63.5 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 81% by SDS-PAGE and Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50 mM Tris-HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
PDGFRα (Platelet-Derived Growth Factor Receptor Alpha) is a transmembrane receptor protein that belongs to the family of receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth, differentiation, migration, and survival. PDGFRα is expressed in a variety of tissues and cell types, including fibroblasts, smooth muscle cells, and certain types of cancer cells. Aberrant activation of PDGFRα has been implicated in several diseases, including cancer, fibrotic disorders, and vascular diseases. PDGFRα mutations, amplifications, and overexpression have been found in various types of cancer, making it a potential target for cancer therapy. Additionally, drugs that target PDGFRα have been approved for the treatment of certain types of cancer, such as gastrointestinal stromal tumors (GIST) and chronic myelomonocytic leukemia (CMML).
Compound name
Kinase
Catalog number
14-735
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-735
Datasheet