MST3, active
N-terminal GST-tagged recombinant, human MST3 amino acids 1-304.
No items found.
Biological information
Background
MST3 (Mammalian sterile 20-like kinase 3) is a serine/threonine protein kinase that belongs to the sterile 20 (STE20) family of kinases. It is involved in a variety of cellular processes, including cell cycle progression, cell migration, and apoptosis. Research has suggested that MST3 plays a role in several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. It has been shown to promote cancer cell proliferation and survival, and inhibition of MST3 has been suggested as a potential cancer therapy. Additionally, MST3 has been implicated in the regulation of neuronal survival and synaptic plasticity, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Target class
Kinase
Family
STE
Accession number
NM_001032296.2; NM_003576.3
Target Name
MST3, active
Target Alias
STK24, MST3B, MST3, MST-3, STK3
Origin
Human
Theori. MW
61.2 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 98.5% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Protein in 50mM Tris/HCl pH7.5,
300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose,
1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
MST3 (Mammalian sterile 20-like kinase 3) is a serine/threonine protein kinase that belongs to the sterile 20 (STE20) family of kinases. It is involved in a variety of cellular processes, including cell cycle progression, cell migration, and apoptosis. Research has suggested that MST3 plays a role in several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. It has been shown to promote cancer cell proliferation and survival, and inhibition of MST3 has been suggested as a potential cancer therapy. Additionally, MST3 has been implicated in the regulation of neuronal survival and synaptic plasticity, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Compound name
Kinase
Catalog number
14-695
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-695
Datasheet