MSK2, active
N-terminal 6His-tagged recombinant, human MSK2 amino acids 2-end.
No items found.
Biological information
Background
MSK1 (mitogen- and stress-activated protein kinases-1, ribosomal protein S6 kinase, 90kDa, polypeptide 5) and MSK2 (mitogen- and stress-activated protein kinases-2, ribosomal protein S6 kinase, 90kDa, polypeptide 4) are activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK is activated by UV radiation, oxidative stress, and other cell-damaging stimuli. MSK may mediate the growth factor and stress-induced activation of CREB.
GenBank AJ010119
Target class
Kinase
Family
AGC
Accession number
NM_001006944.1; NM_003942.2
Target Name
MSK2, active
Target Alias
RPS6KA4, MSK2, RSK-B, RSKB
Origin
Human
Theori. MW
89.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose. Activated using MAP Kinase 2/Erk2, active (Catalog # 14-173) and repurified using Ni2+/NTA-agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
MSK1 (mitogen- and stress-activated protein kinases-1, ribosomal protein S6 kinase, 90kDa, polypeptide 5) and MSK2 (mitogen- and stress-activated protein kinases-2, ribosomal protein S6 kinase, 90kDa, polypeptide 4) are activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK is activated by UV radiation, oxidative stress, and other cell-damaging stimuli. MSK may mediate the growth factor and stress-induced activation of CREB.
GenBank AJ010119
Compound name
Kinase
Catalog number
14-616
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-616
Datasheet