PIM2, active
N-terminal GST-tagged recombinant, human full length PIM2.
No items found.
Biological information
Background
Protein serine/threonine kinase PIM2 is a member of a small family of highly homologous kinases, including PIM1, PIM2, and PIM3, and all members are expressed in the thymus. Pim plays a role in cell survival, proliferation, differentiation and tumorigenesis. Overexpression of each of these members can promote lymphomagenesis in mice. Inhibition of PIM2 may be useful in the treatment of chronic lymphocytic leukemia (B-CLL) and non-Hodgkin's lymphomas (NHL).
GenBank U77735
Target class
Kinase
Family
CAMK
Accession number
NM_006875.2
Target Name
PIM2, active
Target Alias
PIM2, Pim-2h
Origin
Human
Theori. MW
63.4 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Protein serine/threonine kinase PIM2 is a member of a small family of highly homologous kinases, including PIM1, PIM2, and PIM3, and all members are expressed in the thymus. Pim plays a role in cell survival, proliferation, differentiation and tumorigenesis. Overexpression of each of these members can promote lymphomagenesis in mice. Inhibition of PIM2 may be useful in the treatment of chronic lymphocytic leukemia (B-CLL) and non-Hodgkin's lymphomas (NHL).
GenBank U77735
Compound name
Kinase
Catalog number
14-607
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-607
Datasheet