PI3 Kinase (p110δ/p85α), active
Complex of N-terminal 6His-tagged recombinant, human full length p110δ and untagged recombinant, human full length p85α.
No items found.
Biological information
Background
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.
GenBank NM_005026. The recombinant protein contains the amino acid substitution N253S with respect to this accession number. This conflict is reported inGenBank Y10055 and U57843. The residue coordinates in the native sequence are given / GenBank XM_043865
Target class
Kinase
Family
PI3K/PI4K
Accession number
NM_005026.2
Target Name
PI3 Kinase (p110δ/p85α), active
Target Alias
PIK3CD, p110d, PI3K, p110D, p110delta
Origin
Human
Theori. MW
121.6 kDa (p110δ), 83.7 kDa (p85α)
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.
GenBank NM_005026. The recombinant protein contains the amino acid substitution N253S with respect to this accession number. This conflict is reported inGenBank Y10055 and U57843. The residue coordinates in the native sequence are given / GenBank XM_043865
Compound name
Kinase
Catalog number
14-604
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-604
Datasheet