MAPKAP Kinase 3, active
N-terminal GST-tagged recombinant, human MAPKAP Kinase 3 amino acids 2-end; activated using SAPK2a (Catalog #14-587).
No items found.
Biological information
Background
Mitogen-activated protein kinase (MAPK)-activated protein kinase 3 (MAPKAPK3) mediates multiple p38 MAPK-dependent inflammatory responses. This kinase can be activated in response to cellular stress and proinflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. p38 MAP kinase, activated through MKK3, is required for the production of inflammatory cytokines by both antigen-presenting cells and CD4+ T cells.
GenBank NM_004635
Target class
Kinase
Family
CAMK
Accession number
NM_004635.3
Target Name
MAPKAP Kinase 3, active
Target Alias
MAPKAPK3, MAPKAP, MAPKAP3, 3PK, MAPKAPK-3, 3pK
Origin
Human
Theori. MW
69.8 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Mitogen-activated protein kinase (MAPK)-activated protein kinase 3 (MAPKAPK3) mediates multiple p38 MAPK-dependent inflammatory responses. This kinase can be activated in response to cellular stress and proinflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. p38 MAP kinase, activated through MKK3, is required for the production of inflammatory cytokines by both antigen-presenting cells and CD4+ T cells.
GenBank NM_004635
Compound name
Kinase
Catalog number
14-585
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-585
Datasheet