NEK2, active
N-terminal 6His-tagged recombinant, human full length NEK2.
No items found.
Biological information
Background
NEK (NIMA-Related Kinase) Ser/Thr kinase family includes at least 11 members and is involved in regulation of mitosis. Overexpression of active NEK2 (NLK1) induces a striking splitting of centrosomes, whereas prolonged expression of either active or inactive NEK2 leads to dispersal of centrosomal material and loss of a focused microtubule-nucleating activity.
GenBank NM_002497
Target class
Kinase
Family
Other
Accession number
NM_002497.2
Target Name
NEK2, active
Target Alias
NEK2, NLK1, NLK, NEK2A, HsPK21
Origin
Human
Theori. MW
52.8 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
NEK (NIMA-Related Kinase) Ser/Thr kinase family includes at least 11 members and is involved in regulation of mitosis. Overexpression of active NEK2 (NLK1) induces a striking splitting of centrosomes, whereas prolonged expression of either active or inactive NEK2 leads to dispersal of centrosomal material and loss of a focused microtubule-nucleating activity.
GenBank NM_002497
Compound name
Kinase
Catalog number
14-545
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-545
Datasheet