MKK4/SKK1, unactive
N-terminal GST-tagged recombinant, murine MKK4 amino acids 35-397.
No items found.
Biological information
Background
MKK4 is a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis.
EMBL U18310
Target class
Kinase
Family
STE
Accession number
NM_003010.2
Target Name
MKK4/SKK1, unactive
Target Alias
MAP2K4, MKK4, JNKK, MEK4, MAPKK4, JNKK1, SEK1, SERK1, PRKMK4
Origin
Mouse
Theori. MW
65 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
MKK4 is a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis.
EMBL U18310
Compound name
Kinase
Catalog number
14-378
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-378
Datasheet