p38α/SAPK2a, unactive
GST-tagged recombinant, human full length p38α/SAPK2a.
No items found.
Biological information
Background
p38α/SAPK2a Protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
GenBank L35264
Target class
Kinase
Family
CMGC
Accession number
NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1
Target Name
p38α/SAPK2a, unactive
Target Alias
MAPK14, PRKM14, RK, SAPK2A, CSBP1, p38, CSPB1, CSBP, PRKM15, Mxi2, p38ALPHA, MXI2, EXIP, CSBP2
Origin
Human
Theori. MW
67.7 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
p38α/SAPK2a Protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
GenBank L35264
Compound name
Kinase
Catalog number
14-252
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-252
Datasheet