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DDLAC
Soft proprietary stabilization reagents

DDLAC Reagent

DDLAC is a non-ionic detergent / surfactant with a lactobionamide head group and a dodecyl chain.
€ 165.00 (250mg)
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Information

IUPAC name: N-dodecylamine lactobionamide

Compound name: N-dodecylamine lactobionamide (DDLAC)

Catalogue number: DDLAC_250MG
DDLAC_500MG
DDLAC_1G

Molec. Formula: C24H47NO11

CAS: nd

MW: 525.6 g/mol

pKa: na​

Percent Composition: C, 54.84; H, 9.01; N, 2.66; O, 33.48

Production

Physical state: White powder

Purity (HPLC, 214nm): ≤95%

Retention time (RP18 HPLC)b: tR = 14.9 min

CMC: 0.25 mM

Exact mass: 525.3149

Stability: Store in <-20°C freezer out of direct light

Solubility Structure: Soluble in water (1.1 mM), methanol and DMSO

What makes us special

We use a unique & custom-built approach to give you an edge

CALIXAR’s DDLAC is produced into a powder form and is utilized in an aqueous solution or buffer. DDLAC can be mixed with biological materials (biological membranes).

Our clients are able to use DDLAC to aid in the production of lipid detergents, mixed micelles, and protein detergent micelles. DDLAC enables clients to extract, to solubilize and to stabilize native and functional membrane proteins of high medical relevance within a solution.

DDLAC is a fairly mild detergent used to solubilize and stabilize native membrane proteins that are non-ionic. Consequently, as it is not sensitive to ionic strength or pH variations, they are ideal to extract precise membrane proteins.

Application note
Native Full-Length Proteins

CALIXAR’s DDLAC is non-ionic and therefore not sensitive to ionic concentration or pH shifts.  DDLAC is well adapted to extract, to solubilize and to stabilize particular membrane proteins.

Specifically made for Biotech

CALIXAR’s DDLAC (N-dodecylamine lactobionamide) extracts high-quality membrane proteins used for research, drug discovery and structural studies. Our DDLAC is specifically made for pharmaceutical and biotechnology companies, as well as academic teams (biochemists, structural biologists, pharmacologists, virologists) involved in the life science domains.

For any Life Science Project
  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage
More documentation

References

ACS PUBLICATIONS

Lactobionamide Surfactants with Hydrogenated, Perfluorinated or Hemifluorinated Tails

Lebaupain F. et al. 2006
Read more
Conformational antibody development
Vaccine development
Ligand high-throughput screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets
Conformational antibody development
Vaccine development
High-throughput ligand screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

Contact us