CALIXAR's High Tech Drug Discovery
CALIXAR's distinguished-quality native membrane protein targets are ideal to enable small molecule drug discovery.
CALIXAR produces high-quality native membrane protein targets to facilitate small molecules (ligand) discovery by screening (Fragment-based Drug Discovery – FBDD) and by Structure-Based Drug Design (SBDD).
Our protein targets are congruous with all screening platforms: (High Throughput Screening, NMR, SPR, Mass Spectrometry, crystallography, cryo-EM)
In addition, CALIXAR provides a more immeasurable understanding of ligand/protein recognition and promotes the discovery of the mechanism of action (orthosteric vs allosteric).
Best in class Membrane Proteins for Drug Discovery
High-quality native, pure, stable and functional membrane protein targets compatible with all drug discovery projects.
CALIXAR’s technology sustains the structural and functional integrities of membrane protein targets providing accurate discovery of hits/leads/candidates with therapeutic potential.
Traditionally, drug discovery was performed with low-quality membrane protein targets due to low stability, inaccurate conformation (mutations, truncations), and assay incompatibilities (protein buffer conditions, protein stability).
However, CALIXAR delivers high-quality native, pure, stable and functional membrane protein targets compatible with all drug discovery proposes.
Our membrane proteins are ideal for drug discovery scientists such as Biochemists, Structural Biologists, Biophysicists, and Medicinal Chemists. Our technology is also made for Pharma, biotechs, and academics involved in FBDD, SBDD and/or hit to lead optimization.
Obtain access to CALIXAR's Drug Discovery Technology
All of our clients get access to our proprietary technology and expertise (8 patent families, more than 28 publications).
The CALIXAR® platform uses patented technologies only possible for clients under specific arrangements (license, co-development, and service).
You can leverage CALIXAR’s proprietary technology as well as other best-in-class membrane protein technology not obtainable anywhere else on the market.