PIM3, active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human Pim-3.
No items found.
Biological information
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Target class
Kinase
Family
CAMK
Accession number
NM_001001852.2
Target Name
PIM3, active Human Recombinant Kinase Protein
Target Alias
PIM3, pim-3
Origin
Human
Theori. MW
39.6 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 80% by SDS-PAGE and
Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50mM Tris/HCl pH7.5,
300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM
benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen
solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Compound name
Kinase
Catalog number
14-738
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Target class
Kinase
Family
CAMK
Subfamily
Protein Name
Pim3
Protein Alias
PIM3, pim-3
Accession Number
NM_001001852.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Target class
Kinase
Family
CAMK
Accession Number
NM_001001852.2
Target Name
Pim3
Target Alias
PIM3, pim-3
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 80% by SDS-PAGE and
Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Pim-3 (Proviral integration site for Moloney murine leukemia virus 3) is a serine/threonine protein kinase that belongs to the Pim family of kinases. It is involved in a variety of cellular processes, including cell proliferation, survival, differentiation, and metabolism. Research has suggested that Pim-3 plays a role in several diseases, including cancer, cardiovascular diseases, and inflammatory disorders. It has been shown to promote cancer cell proliferation and survival, and inhibition of Pim-3 has been suggested as a potential cancer therapy. Additionally, Pim-3 has been implicated in the regulation of T-cell development and function, making it a potential target for the treatment of autoimmune diseases and graft-versus-host disease.
Target class
Kinase
Family
CAMK
Accession Number
NM_001001852.2
Target Name
Pim3
Target Alias
PIM3, pim-3
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 80% by SDS-PAGE and
Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only