p38γ/SAPK3, active Human Recombinant Kinase Protein
GST-tagged recombinant, human full length p38γ/SAPK3.
No items found.
Biological information
Background
Mitogen-activated protein (MAP) kinases are proline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been studied in detail: the extracellular signal-regulated kinases (ERK), the c-Jun NH2-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinase group, which includes the isoforms p38a, p38b, p38g and p38d, activates the transcription factors CREB, ATF1, ATF2, CHOP, and MEF-2C. The p38 MAP kinase also activates other protein kinases, such as Mapkap-2, Mapkap-3, and Mnk1/2.
Target class
Kinase
Family
CMGC
Accession number
NM_002567.2
Target Name
p38γ/SAPK3, active Human Recombinant Kinase Protein
Target Alias
PEBP1, PEBP, PEBP-1, HCNPpp, RKIP, PBP, HCNP
Origin
Human
Theori. MW
69 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Purity 89.7% by SDS-PAGE and Coomassie staining.
Purification method
Glutathione Sepharose™ affinity chromatography after activation with SKK3/MEK6
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Mitogen-activated protein (MAP) kinases are proline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been studied in detail: the extracellular signal-regulated kinases (ERK), the c-Jun NH2-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinase group, which includes the isoforms p38a, p38b, p38g and p38d, activates the transcription factors CREB, ATF1, ATF2, CHOP, and MEF-2C. The p38 MAP kinase also activates other protein kinases, such as Mapkap-2, Mapkap-3, and Mnk1/2.
Compound name
Kinase
Catalog number
14-246
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
Mitogen-activated protein (MAP) kinases are proline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been studied in detail: the extracellular signal-regulated kinases (ERK), the c-Jun NH2-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinase group, which includes the isoforms p38a, p38b, p38g and p38d, activates the transcription factors CREB, ATF1, ATF2, CHOP, and MEF-2C. The p38 MAP kinase also activates other protein kinases, such as Mapkap-2, Mapkap-3, and Mnk1/2.
Target class
Kinase
Family
CMGC
Subfamily
Protein Name
p38γ/SAPK3
Protein Alias
PEBP1, PEBP, PEBP-1, HCNPpp, RKIP, PBP, HCNP
Accession Number
NM_002567.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Mitogen-activated protein (MAP) kinases are proline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been studied in detail: the extracellular signal-regulated kinases (ERK), the c-Jun NH2-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinase group, which includes the isoforms p38a, p38b, p38g and p38d, activates the transcription factors CREB, ATF1, ATF2, CHOP, and MEF-2C. The p38 MAP kinase also activates other protein kinases, such as Mapkap-2, Mapkap-3, and Mnk1/2.
Target class
Kinase
Family
CMGC
Accession Number
NM_002567.2
Target Name
p38γ/SAPK3
Target Alias
PEBP1, PEBP, PEBP-1, HCNPpp, RKIP, PBP, HCNP
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed in E. coli
Purity
Purity 89.7% by SDS-PAGE and Coomassie staining.
Purification method
Glutathione Sepharose™ affinity chromatography after activation with SKK3/MEK6
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Mitogen-activated protein (MAP) kinases are proline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been studied in detail: the extracellular signal-regulated kinases (ERK), the c-Jun NH2-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinase group, which includes the isoforms p38a, p38b, p38g and p38d, activates the transcription factors CREB, ATF1, ATF2, CHOP, and MEF-2C. The p38 MAP kinase also activates other protein kinases, such as Mapkap-2, Mapkap-3, and Mnk1/2.
Target class
Kinase
Family
CMGC
Accession Number
NM_002567.2
Target Name
p38γ/SAPK3
Target Alias
PEBP1, PEBP, PEBP-1, HCNPpp, RKIP, PBP, HCNP
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed in E. coli
Purity
Purity 89.7% by SDS-PAGE and Coomassie staining.
Purification method
Glutathione Sepharose™ affinity chromatography after activation with SKK3/MEK6
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only