NEK4, active Human Recombinant Kinase Protein
10 µg of active NEK4. C-Terminal 6His-tagged, recombinant, human NEK4, full length.
No items found.
Biological information
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Target class
Kinase
Family
Accession number
NM_003157.4
Target Name
NEK4, active Human Recombinant Kinase Protein
Target Alias
NIMA Related Kinase 4NIMA (Never In Mitosis Gene A)-Related KinaseSerine/Threonine-Protein Kinase Nek4Serine/Threonine-Protein Kinase NRK2Never In Mitosis A-Related Kinase 4Serine/Threonine Protein Kinase-2NimA-Related Protein Kinase 4
Origin
Human
Theori. MW
96 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
52% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immobilized metal affinity chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Compound name
Kinase
Catalog number
15-033
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Target class
Kinase
Family
Subfamily
Protein Name
NEK4
Protein Alias
NIMA Related Kinase 4NIMA (Never In Mitosis Gene A)-Related KinaseSerine/Threonine-Protein Kinase Nek4Serine/Threonine-Protein Kinase NRK2Never In Mitosis A-Related Kinase 4Serine/Threonine Protein Kinase-2NimA-Related Protein Kinase 4
Accession Number
NM_003157.4
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C.
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Target class
Kinase
Family
Accession Number
NM_003157.4
Target Name
NEK4
Target Alias
NIMA Related Kinase 4NIMA (Never In Mitosis Gene A)-Related KinaseSerine/Threonine-Protein Kinase Nek4Serine/Threonine-Protein Kinase NRK2Never In Mitosis A-Related Kinase 4Serine/Threonine Protein Kinase-2NimA-Related Protein Kinase 4
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
52% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immobilized metal affinity chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Biological Information
Background
NEK4 is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Target class
Kinase
Family
Accession Number
NM_003157.4
Target Name
NEK4
Target Alias
NIMA Related Kinase 4NIMA (Never In Mitosis Gene A)-Related KinaseSerine/Threonine-Protein Kinase Nek4Serine/Threonine-Protein Kinase NRK2Never In Mitosis A-Related Kinase 4Serine/Threonine Protein Kinase-2NimA-Related Protein Kinase 4
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
52% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immobilized metal affinity chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only